Since the TRIPS agreement came into force, it has been criticized by developing countries, scientists and non-governmental organizations. While some of this criticism is generally opposed to the WTO, many proponents of trade liberalization also view TRIPS policy as a bad policy. The effects of the concentration of WEALTH of TRIPS (money from people in developing countries for copyright and patent holders in industrialized countries) and the imposition of artificial shortages on citizens of countries that would otherwise have had weaker intellectual property laws are common bases for such criticisms. Other critics have focused on the inability of trips trips to accelerate the flow of investment and technology to low-income countries, a benefit that WTO members achieved prior to the creation of the agreement. The World Bank`s statements indicate that TRIPS have clearly not accelerated investment in low-income countries, whereas they may have done so for middle-income countries.  As part of TRIPS, long periods of patent validity were examined to determine the excessive slowdown in generic drug entry and competition. In particular, the illegality of preclinical testing or the presentation of samples to be authorized until a patent expires have been accused of encouraging the growth of certain multinationals and not producers in developing countries. Unlike other IP agreements, TRIPS have an effective enforcement mechanism. States can be disciplined by the WTO dispute settlement mechanism. An agreement reached in 2003 relaxed domestic market requirements and allows developing countries to export to other countries with a public health problem as long as exported drugs are not part of a trade or industrial policy.
 Drugs exported under such regulations may be packaged or coloured differently to prevent them from affecting the markets of industrialized countries. Among these agreements, the ip rights trade (TRIPS) aspects are expected to have the greatest impact on the pharmaceutical sector and access to medicines. The TRIPS agreement has been in force since 1995 and is the most comprehensive multilateral IP agreement to date. The TRIPS agreement introduced global minimum standards for the protection and enforcement of almost all forms of intellectual property rights (IPRs), including patent rights. International agreements prior to TRIPS did not contain minimum patent standards. At the time negotiations began, more than 40 countries around the world did not grant patent protection for pharmaceuticals. The TRIPS agreement now requires all WTO members, with a few exceptions, to adapt their legislation to minimum standards of intellectual property protection. In addition, the TRIPS agreement introduced detailed obligations to respect intellectual property rights.